Successful percutaneous intervention in a rare case of aberrant systemic artery to a normal lung presented with hemoptysis.

Aberrant systemic artery to the lung without evidence of sequestration is a rare congenital anomaly. Treatment of choice for this anomaly is controversial. A 27-year-old man with bicuspid aortic valve (AV) and a history of AV replacement was admitted to our center with hemoptysis. Aberrant systemic artery to the lung without sequestration was diagnosed. Endovascular closure of aberrant vessel with septal occluder was performed. After 2 years the previous device was embolized to the distal part and he came back with hemoptysis. The second endovascular procedure was performed with a larger device with a successful result. There are surgical and interventional treatment options for systemic arterialization to a normal lung without sequestration. In this case we used Amplatzer septal occluder (St. Jude Medical, Minneapolis, MN, USA) for occlusion of the aberrant vessel. .

The Association of Serum Hepcidin Levels and Insulin Resistance in PCOS Patients: A Case-Control Study.

Objective: To investigate the relationship between insulin resistance and hepcidin levels in patients with PCOS. Materials and methods: In this case-control study fifty- six patients with PCOS and forty - one healthy control subjects were included. Plasma levels of hepcidin, IL-6, Serum Insulin and ferritin using ELISA method, serum iron levels using a spectrophotometric method, and Insulin resistance by using HOMA were measured in the two groups of PCOS (case group) and healthy subjects (control group). The results were analyzed by student's t-test, General Linear Model, Binary logistic and linear regression tests. Results: The mean hepcidin level was 1.97 ± 0.53 pg/ml and 2.40 ± 0.25pg/ml in the case and control groups, respectively. The t-test results showed a significant difference between the two groups (p = 0.0001). The mean of insulin level in case and control group was 30.65 ± 15.02g/dl and 14.71 ± 10.46g/dl, respectively. The t-test analysis indicated a significant difference between the two groups (p = 0.0001). There was an inverse relationship between the level of hepcidin with HOMA-IR (ß = -0.629, p = 0.04), and IL-6 (ß = -0.243, p = 0.015) in both groups. The adjusted OR proved a statistically significant association between serum hepcidin (OR = 0.063; 95 % CI: 0.01-0.385, p-value = 0. 003) and HOMA (OR = 1.569; 95 % CI: 1.254-1.964, p-value = 0.001) with PolycysticOvarian Syndrome. Conclusion: There was an inverse relationship between hepcidin levels and insulin resistance in both groups meaning decrease in hepcidin levels and increase in insulin resistance may increase the risk of PCOS.